Intact human erythrocytes prevent hydrogen peroxide-mediated damage to isolated perfused rat lungs and cultured bovine pulmonary artery endothelial cells.
نویسندگان
چکیده
Addition of untreated or glutaraldehyde-fixed human erythrocytes decreased hydrogen peroxide (H2O2)-mediated acute edematous injury in isolated rat lungs, H2O2-induced damage to cultured bovine pulmonary artery endothelial cells, and H2O2-dependent oxidation of reduced cytochrome C in vitro. The results suggest that intact erythrocytes can scavenge H2O2, and as a result, protect the lung and possibly other tissues from damage.
منابع مشابه
Rapid Publications Intact Human Erythrocytes Prevent Hydrogen Peroxide-mediated Damage to Isolated Perfused Rat Lungs and Cultured Bovine Pulmonary Artery Endothelial Cells
Portions ofthe work were presented by Ms. Toth at the Annual Meeting ofthe Western Society for Clinical Investigation, where she was awarded the Western Section-American Federation of Clinical Research Medical Student Pulmonary Subspecialty Prize. The work has also been selected for presentation at meetings of the American Society for Clinical Investigation and at the National Medical Student R...
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عنوان ژورنال:
- The Journal of clinical investigation
دوره 74 1 شماره
صفحات -
تاریخ انتشار 1984